Fexofenadine Brain Exposure and the Influence of Blood-Brain Barrier P- glycoprotein Following Fexofenadine and Terfenadine Administration
نویسندگان
چکیده
Division of Pharmacotherapy and Experimental Therapeutics, School of Pharmacy, University of North Carolina at Chapel Hill, Chapel Hill, NC (R.Z., G.M.P.); Drug Disposition, Eli Lilly and Company, Indianapolis, IN 46285 (J.C.K.); Division of Molecular Pharmaceutics, School of Pharmacy, University of North Carolina at Chapel Hill, Chapel Hill, NC (S.B.Y., A.S.B.) DMD Fast Forward. Published on December 29, 2008 as doi:10.1124/dmd.107.019893
منابع مشابه
Fexofenadine brain exposure and the influence of blood-brain barrier P-glycoprotein after fexofenadine and terfenadine administration.
P-glycoprotein (P-gp) plays an important role in determining net brain uptake of fexofenadine. Initial in vivo experiments with 24-h subcutaneous osmotic minipump administration demonstrated that fexofenadine brain penetration was 48-fold higher in mdr1a(-/-) mice than in mdr1a(+/+) mice. In contrast, the P-gp efflux ratio at the blood-brain barrier (BBB) for fexofenadine was only approximately...
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